Androstenedione: Is It Safe and Effective?

I am often asked by men if taking androstenedione is a substitute for testosterone in those who have symptoms of low T and don’t want to take testosterone.

Androstenedione (ASD) is a steroid hormone used by the body to make testosterone and estrogen. Studies on men taking 100-300mg\day have not shown any increase in muscle strength, muscle size, or lean body mass when used for 2-3 months in connection with weight training. ASD does not increasing energy or improve sexual desire and function.

In addition to not being effective ASD is POSSIBLY UNSAFE for most men when taken by mouth. Some side effects experienced by men include reduced sperm production, shrunken testicles, painful or prolonged erections, breast development, behavioral changes, heart disease, and others. ASD can increase the chances of getting cancers of the breast, prostate, or pancreas; and it is poisonous to the liver. Certainly if you have liver disease, don’t take ASD. Even if you don’t have liver disease, it’s best to get liver function tests if you take androstenedione.

Bottom Line: ASD has not shown to be helpful for men with low T or symptoms of low T. ASD may also be dangerous to your health and probably should be avoided by men with low T.

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