Archive for the ‘androstenedione’ Category

Supplements and Testicular Cancer-Is There a Relationship?

May 4, 2015

Testicle cancer is the most common cancer in men between the age of 20-40. The cause of testicle cancer is not known but a recent report suggests a relationship between the use supplements and testicle cancer.
In the United States, 8,500 men are diagnosed with the disease every year. Exactly what causes testicular cancer remains largely a mystery to the scientific community, but a new study published recently in the British Journal of Cancer has uncovered an unexpectedly high correlation between muscle-building supplements and testicle cancer.

The study was conducted by interviewing 356 men who had been diagnosed with testicular germ cell cancer, and 513 men who had not. Researchers asked not only about their supplement use, but also about other factors such as smoking, drinking, exercise habits, family history of testicular cancer, and prior injury to the groin, in order to rule out confounding variables. Supplement use was defined as consuming one or more supplements—such as pills and powders containing creatine or androstenedione—at least once a week for four consecutive weeks or more.

After accounting for confounding influences, as well as age, race, and other demographics, researchers found that men who used supplements had a 65 percent greater risk of having developed testicular cancer than men who did not use supplements.

They also found evidence that application of supplements beyond the moderate definition of supplement use increased risk even further:
Men who used more than one kind of supplement had a 177 percent greater risk.
Men who used supplements for three years or longer had a 156 percent greater risk.
Men who started using supplements at age 25 or younger had a 121 percent greater risk.

Inspired by mounting evidence that at least some supplement ingredients may damage the testes, the study is the first of its kind to explore the possible link between supplements and testicular cancer. The authors hope that future studies and experiments will substantiate their findings.

Bottom Line: No one can say with any degree of certainty that supplements cause testicle cancer. However, until the study is confirmed, the question men everywhere should be asking themselves is, “are the gains worth it?”

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Androstenedione: Is It Safe and Effective?

February 27, 2015

I am often asked by men if taking androstenedione is a substitute for testosterone in those who have symptoms of low T and don’t want to take testosterone.

Androstenedione (ASD) is a steroid hormone used by the body to make testosterone and estrogen. Studies on men taking 100-300mg\day have not shown any increase in muscle strength, muscle size, or lean body mass when used for 2-3 months in connection with weight training. ASD does not increasing energy or improve sexual desire and function.

In addition to not being effective ASD is POSSIBLY UNSAFE for most men when taken by mouth. Some side effects experienced by men include reduced sperm production, shrunken testicles, painful or prolonged erections, breast development, behavioral changes, heart disease, and others. ASD can increase the chances of getting cancers of the breast, prostate, or pancreas; and it is poisonous to the liver. Certainly if you have liver disease, don’t take ASD. Even if you don’t have liver disease, it’s best to get liver function tests if you take androstenedione.

Bottom Line: ASD has not shown to be helpful for men with low T or symptoms of low T. ASD may also be dangerous to your health and probably should be avoided by men with low T.